Original Research

Revealing grand-paternal programming of lipid metabolism using a novel computational tool, Samuel Furse, A. J. Watkins, D. Chiarugi, N. Hojat, J. Smith, H. E. L. Williams, A. Koulman.  BioRxiv, 2020, DOI: 10.1101/2020.06.23.166819 (under review at Nature Metabolism)

Lipid extraction from dried blood spots and dried milk spots for high throughput lipidomics, Samuel Furse, A. Koulman.  BioRxiv, 2020, DOI: 10.1101/2020.06.22.165514 (Under review at J. Ped. Gastro. Nutr.)

Extraction of lipids from liquid biological samples for high throughput lipidomics, Samuel Furse, A. J. Watkins, A. Koulman. Molecules, 2020, 25, 3192. DOI: 10.3390/molecules25143192

A high throughput platform for detailed lipidomic analysis of a range of mouse and human tissues, Samuel Furse, D. Fernandez-Twinn, B. Jenkins, C. L. Meek, H. E. L. Williams, G. C. S. Smith, D. S. Charnock-Jones, S. E. Ozanne, A. Koulman. Analytical and Bioanalytical Chemistry, 2020, 412, 2851. DOI: 10.1007/s00216-020-02511-0

Variants in MARC1 and HSD17B13 reduce severity of NAFLD in children, perturb phospholipid metabolism, and suppress fibrotic pathways, C. A. Hudert, A. Alisi, Q. M. Anstee, A. Crudele, L. G. Draijer, EU-PNAFLD investigators, Samuel Furse, J. G. Hengstler, B. Jenkins, K. Karnebeek, D. A. Kelly, B. G. Koot, A. Koulman, D. Meierhofer, S. G. Snowden, I. van Mourik, A. Vreugdenhil, S. Wiegand, J. P. Mann.  medRxiv, 2020, DOI: 10.1101/2020.06.05.20120956

Plasma lipidomics distinguishes NASH and fibrosis from simple fatty liver in children, J. P. Mann, Samuel Furse, S. G. Snowden, A. Alisi, L. Draijer, EU-PNAFLD Investigators, B. Jenkins, K. Karnebeek, D. A. Kelly, B. G. Koot, A. Mosca, C. Salvestrini, I. van Mourik, A. Vreugdenhil, M. Zilbauer, A. Koulman. medRxiv, 2020, doi: 10.1101/2020.04.18.20070417 

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals, A. Koulman, Samuel Furse, M. Baumert, G. Goldberg, L. Bluck.  Rapid Communications in Mass Spectrometry, 2019, 33, 1267-1276.  DOI: 10.1002/rcm.8465

Evidence that feeding post partum and exposures in utero shape lipid metabolism in infancy, Samuel Furse, S. G. Snowden, L. Olga, P. Prentice, K. K. Ong, I. A. Hughes, C. L. Acerini, D. B. Dunger, A. Koulman. Scientific Reports, 2019, 9, 14321 DOI: 10.1038/s41598-019-50693-0

Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy, Samuel Furse, S. L. White, C. L. Meek, B. J. Jenkins, C. J. Petry, M. C. Vieira, D. B. Dunger, S. E. Ozanne, L. Poston, A. Koulman. Molecular Omics, 2019, 15, 420-430, DOI: 10.1039/c9mo00117d

Relationship between the lipid composition of maternal plasma and infant plasma through breast milk, Samuel Furse, G. Billing, S. G. Snowden, J. Smith, G. Goldberg, A. Koulman. Metabolomics, 2019, 15, 129. DOI:10.1007/s11306-019-1589-z.

Fermentation of milk into yoghurt and cheese leads to contrasting lipid and glyceride profiles, Samuel Furse*, A. G. Torres, A. Koulman*, Nutrients, 2019, 11, 2178.  DOI: 10.3390/nu11092178

The lipid and glyceride profiles of infant formula differ by manufacturer, region and date sold, Samuel Furse*, A. Koulman, Nutrients, 2019, 11, 1122.  DOI: 10.3390/nu11051122

Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle, Samuel Furse, M. Jakubec, F. Rise, H. E. Williams, C. E. D. Rees, Ø. Halskau, Scientific Reports, 2017.  DOI: 10.1038/s41598-017-06855-z.

Pressure-dependent inverse bicontinuous cubic phase formation in a PI- 4‑phosphate/ phosphatidylcholine system, Samuel Furse, N. J. Brooks, R. Woscholski, P. R. J. Gaffney, R. H. Templer.  Chemical Data Collections, 2016, 3-4, 15-20.  DOI: 10.1016/j.cdc.2016.08.001.

E. coli MG1655 modulates its phospholipid composition through the cell cycle, Samuel Furse*, H. Wienk, R. Boelens, A. I. de Kroon, J. A. Killian. FEBS Letters, 2015, 589, 2726-2730. DOI: 10.1016/j.febslet.2015.07.043. 

The Lipidome and Proteome of Oil Bodies from Helianthus annuus (common sunflower), Samuel Furse, S. Liddell, C. Ortori, H. Williams, D. Neylon, D. J. Scott, D. A. Barrett, D. Gray.  Journal of Chemical Biology, 20136, 63-76. DOI: 10.1007/s12154-012-0090-1.

Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate, Samuel Furse, N.J.Brooks, A. Seddon, R. Woscholski, R.Templer, E.W.Tate, P. Gaffney, O. Ces.  Soft Matter, 2012, 8, 3090-3093. DOI: 10.1039/c2sm07358g.

OB013007_OFC_PUBLICITY

The cover of Issue 7 of Volume 8 of Organic & Biomolecular Chemistry

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity 
Samuel Furse, LokHang Mak, Edward W. Tate, Richard H. Templer, Oscar Ces, Rüdiger Woscholski and Piers R. J. Gaffney.
Organic and Biomolecular Chemistry, 2015, 13, 2001-2011. DOI: http://dx.doi.org/10.1039/c4ob02258k.  Click here for Open Access PDF of the article and here for the cover PDF.  PMID: 25515724

Chemical stress and the cell envelope: the phospholipid fraction [Poster]
Samuel Furse, Anton I. de Kroon and J. Antoinette Killian.
Biophysical Journal, 2014, 106, 508A. DOI: http://dx.doi.org/10.1016/j.bpj.2013.11.2840

The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower)
Samuel Furse, Susan Liddell, Catharine A. Ortori, Huw Williams, D. Cameron Neylon, David J. Scott, David A. Barrett, David A. Gray.
Journal of Chemical Biology, 2013, 6, 63-76. DOI: http://dx.doi.org/10.1007/s12154-012-0090-1.  PMID: 23532185.

The isolation of oil bodies from Oryza sativa bran and studies of their physical properties
Nantaprapa Nantiyakul, Samuel Furse, Ian D. Fisk, Gregory Tucker and David A. Gray.
Journal of Cereal Science, 2013, 57, 141-145.  DOI: http://dx.doi.org/10.1016/j.jcs.2012.11.002.

Phytochemical Composition of Oryza sativa (Rice) Bran Oil Bodies
Nantaprapa Nantiyakul, Samuel Furse, Ian Fisk, Gregory Tucker and David A. Gray.
Journal of the American Oil Chemists Society, 2012, 89, 1867-1872.  DOI: http://dx.doi.org/10.1007/s11746-012-2078-y.

Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate
Samuel Furse, Nicholas J. Brooks, Annela M. Seddon, Rüdiger Woscholski, Richard H. Templer, Edward W. Tate, Piers R. J. Gaffney, Oscar Ces.
Soft Matter, 2012, 8, 3090-3093.  DOI: http://dx.doi.org/10.1039/c2sm07358g.

 

Reviews and Editorials

Do lipid shape the cell cycle? [Review]
Samuel Furse, Gemma C. Shearman.
 Biochimica et Biophysica Acta2017. DOI: http://dx.doi.org/10.1016/j.bbalip.2017.09.010.

Is phosphatidylglycerol essential for terrestrial life? [Review]
Samuel Furse.
Journal of Chemical Biology, 2016. DOI: http://dx.doi.org/10.1007/s12154-016-0159-3.

The 3D distribution of phospholipids in Gram negative bacteria [Mini-review]
Samuel Furse, David J. Scott.
Biochemistry201655, 4742–4747.  DOI: http://dx.doi.org/10.1021/acs.biochem.6b00541.

Detection of mis-folded protein aggregates from a clinical perspective [Mini-review]
Øyvind Strømland, Martin Jakubec, Samuel Furse, Øyvind Halskau.
Journal of Clinical and Translational Research2016, 2, 3. http://dx.doi.org/10.18053/jctres.201604.003

Isolation of lipids from biological samples [Review]
Samuel Furse, Maarten R. Egmond, J. Antoinette Killian.
Molecular Membrane Biology2015, 32, 55-64. http://dx.doi.org/10.3109/09687688.2015.1050468PMID: 26212444

Phosphatidylcholine’s role beyond that of a membrane brick [Mini-review]
Samuel Furse, Anton I. P. M. de Kroon.
Molecular Membrane Biology, 2015, 32, 117-9.  DOI: http://dx.doi.org/10.3109/09687688.2015.1066894. PMID: 26306852

The physical influence of inositides – A disproportionate effect? [Mini-review]
Samuel Furse.
Journal of Chemical Biology, 2015, 8, 1-3. DOI: http://dx.doi.org/10.1007/s12154-014-0117-x. Article available on-line 2014-07-20.  PMID: 25584076.

Lipase activity in lipidomics – A hidden problem?  [Editorial]
Samuel Furse and J. Antoinette Killian.
Molecular Membrane Biology, 2013, 30, 347-9. DOI: http://dx.doi.org/10.3109/09687688.2013.835125.  PMID: 24147976.

 

Grants Awarded

The release of triglycerides from oil bodies by biochemical means, applied for Hermes Innovation Fellowship 2012 (Nottinghamshire Innovation Centre), joint applicant with Dr D. A. Gray.  Application approved with 100% funding.

 

Patents

Rapid Oil Release from Oil Bodies.  David A. Gray, Amit Khosla, Timothy J.  Foster, Elena Marasca, Samuel Furse.  2103.  UK Application Number GB 1208902.5 ref. 11-0084. International Patent Number WO 2013175203 A1

 

Other Information

If you would like any further information on these publications please contact me or the corresponding author named in the publication.

My Scopus author ID is 55048056100.

My ORCiD is 0000-0003-4267-2051, ResearcherID is F-6542-2015 and ImpactStory page is here.

My ResearchGate profile can be found here.

I act as a reviewer by invitation for journals at the Royal Society of Chemistry, the American Chemical Society and the Public Library of Science (PLoS), amongst others.