Dr Samuel Furse

Original Research

Dietary PUFA drives diverse systems-level changes in lipid metabolism, Samuel Furse*, Samuel Virtue, Stuart G. Snowden, Antonio Vidal-Puig, Philip C. Stevenson, Davide Chiarugi, Albert Koulman*, Molecular Metabolism, 2022, 59C, 101457, DOI: 10.1016/j.molmet.2022.101457.

A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia, Samuel Furse & D.S. Fernandez-Twinn, Davide Chiarugi, S. E. Ozanne, A. Koulman, Nutrition & Diabetes, 2022, 12, 8. DOI: 10.1038/s41387-022-00185-4.

Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma, Samuel Furse, A.J. Watkins, H.E.L. Williams, S.G. Snowden, D. Chiarugi, A. Koulman. Metabolomics, 2022, 18, 13. DOI: 10.1007/s11306-022-01869-9.

Gestational diabetes alters lipid metabolism before, during and after pregnancy in mice, Samuel Furse & D.S Fernandez-Twinn, D. Chiarugi, A. Koulman, S. E. Ozanne. Int. J. Mol. Sci., 2021, 22, 7452. DOI: 10.3390/ijms22147452.

Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism, Samuel Furse*, A.J. Watkins, D. Chiarugi, N. Hojat, J. Smith, H.E.L. Williams, A. Koulman*.  Comms Biol., 2021, 4, 163.  DOI: 10.1038/s42003-021-01686-1.

The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote, M. Vítová, V. Lanta, M. Čížková, M. Jakubec, F. Rise, Ø. Halskau, K. Bišová, Samuel Furse* Biochimica et Biophysica Acta, 2021, DOI: 10.1016/j.bbalip.2021.158965.

A pipeline for making ³¹P NMR accessible for small- and large-scale lipidomics studies, Samuel Furse*, H.E.L. Williams*, A.J. Watkins, S. Virtue, A. Vidal-Puig, R. Amarsi, M. Charalambous, A. Koulman*. Anal. and Bioanal. Chem., 2021, 413, 4763.  DOI: 10.1007/s00216-021-03430-4.

Lipid extraction from dried blood spots and dried milk spots for high throughput lipidomics, Samuel Furse, A. Koulman.  Molecular Omics, 2020, DOI: 10.1039/D0MO00102C.

Extraction of lipids from liquid biological samples for high throughput lipidomics, Samuel Furse*, A.J. Watkins, A. Koulman*. Molecules, 2020, 25, 3192. DOI: 10.3390/molecules25143192.

Extraction of lipids from liquid biological samples for high throughput lipidomics, Samuel Furse, A. J. Watkins, A. Koulman. Molecules, 2020, 25, 3192. DOI: 10.3390/molecules25143192

A high throughput platform for detailed lipidomic analysis of a range of mouse and human tissues, Samuel Furse, D. Fernandez-Twinn, B. Jenkins, C. L. Meek, H. E. L. Williams, G. C. S. Smith, D. S. Charnock-Jones, S. E. Ozanne, A. Koulman. Analytical and Bioanalytical Chemistry, 2020, 412, 2851. DOI: 10.1007/s00216-020-02511-0

Evidence that feeding post partum and exposures in utero shape lipid metabolism in infancy, Samuel Furse, S. G. Snowden, L. Olga, P. Prentice, K. K. Ong, I. A. Hughes, C. L. Acerini, D. B. Dunger, A. Koulman. Scientific Reports, 2019, 9, 14321 DOI: 10.1038/s41598-019-50693-0

Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy, Samuel Furse, S. L. White, C. L. Meek, B. J. Jenkins, C. J. Petry, M. C. Vieira, D. B. Dunger, S. E. Ozanne, L. Poston, A. Koulman. Molecular Omics, 2019, 15, 420-430, DOI: 10.1039/c9mo00117d

Relationship between the lipid composition of maternal plasma and infant plasma through breast milk, Samuel Furse, G. Billing, S. G. Snowden, J. Smith, G. Goldberg, A. Koulman. Metabolomics, 2019, 15, 129. DOI:10.1007/s11306-019-1589-z.

Fermentation of milk into yoghurt and cheese leads to contrasting lipid and glyceride profiles, Samuel Furse*, A. G. Torres, A. Koulman*, Nutrients, 2019, 11, 2178.  DOI: 10.3390/nu11092178

The lipid and glyceride profiles of infant formula differ by manufacturer, region and date sold, Samuel Furse*, A. Koulman, Nutrients, 2019, 11, 1122.  DOI: 10.3390/nu11051122

Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle, Samuel Furse, M. Jakubec, F. Rise, H. E. Williams, C. E. D. Rees, Ø. Halskau, Scientific Reports, 2017.  DOI: 10.1038/s41598-017-06855-z.

Pressure-dependent inverse bicontinuous cubic phase formation in a PI- 4‑phosphate/ phosphatidylcholine system, Samuel Furse, N. J. Brooks, R. Woscholski, P. R. J. Gaffney, R. H. Templer.  Chemical Data Collections, 2016, 3-4, 15-20.  DOI: 10.1016/j.cdc.2016.08.001.

E. coli MG1655 modulates its phospholipid composition through the cell cycle, Samuel Furse*, H. Wienk, R. Boelens, A. I. de Kroon, J. A. Killian. FEBS Letters, 2015, 589, 2726-2730. DOI: 10.1016/j.febslet.2015.07.043. 

The Lipidome and Proteome of Oil Bodies from Helianthus annuus (common sunflower), Samuel Furse, S. Liddell, C. Ortori, H. Williams, D. Neylon, D. J. Scott, D. A. Barrett, D. Gray.  Journal of Chemical Biology, 2013, 6, 63-76. DOI: 10.1007/s12154-012-0090-1.

Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate, Samuel Furse, N.J.Brooks, A. Seddon, R. Woscholski, R.Templer, E.W.Tate, P. Gaffney, O. Ces.  Soft Matter, 2012, 8, 3090-3093. DOI: 10.1039/c2sm07358g.

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity 
Samuel Furse, LokHang Mak, Edward W. Tate, Richard H. Templer, Oscar Ces, Rüdiger Woscholski and Piers R. J. Gaffney. Organic and Biomolecular Chemistry, 2015, 13, 2001-2011. DOI: http://dx.doi.org/10.1039/c4ob02258k.  Click here for Open Access PDF of the article and here for the cover PDF.  PMID: 25515724

Chemical stress and the cell envelope: the phospholipid fraction [Poster]
Samuel Furse, Anton I. de Kroon and J. Antoinette Killian. Biophysical Journal, 2014, 106, 508A. DOI: http://dx.doi.org/10.1016/j.bpj.2013.11.2840

The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower)
Samuel Furse, Susan Liddell, Catharine A. Ortori, Huw Williams, D. Cameron Neylon, David J. Scott, David A. Barrett, David A. Gray. Journal of Chemical Biology, 2013, 6, 63-76. DOI: http://dx.doi.org/10.1007/s12154-012-0090-1.  PMID: 23532185.

Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate
Samuel Furse, Nicholas J. Brooks, Annela M. Seddon, Rüdiger Woscholski, Richard H. Templer, Edward W. Tate, Piers R. J. Gaffney, Oscar Ces.  Soft Matter, 2012, 8, 3090-3093.  DOI: http://dx.doi.org/10.1039/c2sm07358g.

 

Original Research (co-author)

Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex- dependent manner, L. C. Pantaleão, I. Inzani, Samuel Furse, E. Loche, A. Hufnagel, T. Ashmore, H. L. Blackmore, B. Jenkins, A. A. M. Carpenter, A. Wilczynska, M. Bushell, A. Koulman, D. S. Fernandez-Twinn, S. E. Ozanne. eLife, 2022, DOI: 10.7554/eLife.69078.

Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study, J.P. Mann, B. Jenkins, Samuel Furse, S. G. Snowden, A. Alisi, L.G. Draijer, K. Karnebeek, D.A. Kelly, B.G. Koot, A. Mosca, C. Salvestrini, I. van Mourik, A. Vreugdenhil, M. Zilbauer, A. Koulman.  Journal of Pediatric Gastroenterology and Nutrition, 2022, DOI: 10.1097/MPG.0000000000003418.

SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity. L. Olga, J. A. van Diepen, I. Bobeldijk-Pastorova, G. Gross, P. M. Prentice, S. G. Snowden, Samuel Furse, T. Kooistra, I. A. Hughes, M. H. Schoemaker, E. A. F. van Tol, W. van Duyvenvoorde, P. Y. Wielinga, K. K. Ong, D. B. Dunger, R. Kleemann, A. Koulman. 2021, EBioMedicine, DOI: 10.1016/j.ebiom.2020.103198

Variants in MARC1 and HSD17B13 reduce severity of NAFLD in children, perturb phospholipid metabolism, and suppress fibrotic pathways, C. A. Hudert, A. Alisi, Q. M. Anstee, A. Crudele, L. G. Draijer, EU-PNAFLD investigators, Samuel Furse, J. G. Hengstler, B. Jenkins, K. Karnebeek, D. A. Kelly, B. G. Koot, A. Koulman, D. Meierhofer, S. G. Snowden, I. van Mourik, A. Vreugdenhil, S. Wiegand, J. P. Mann. medRxiv, 2020, DOI: 10.1101/2020.06.05.20120956

Microencapsulated algal feeds as a sustainable replacement diet for broodstock in commercial bivalve aquaculture. D.F. Willer, Samuel Furse, D.C. Aldridge.  Scientific Reports, 2020, DOI: 10.1038/s41598-020-69645-0

The Role of Tryptophan‐Nicotinamide (TRP‐NAM) Pathway in Malnutrition Induced Liver Dysfunction. G. Hu, C. Ling, L. Chi, Samuel Furse, A. Koulman, R, Bandsma. FASEB Journal, 2020, 34, 1. DOI: 10.1096/fasebj.2020.34.s1.08970

Cholesterol-containing lipid nanodiscs promote an α-Synuclein binding mode that accelerates oligomerization, M. Jakubec, E. Bariås, Samuel Furse, M. L. Govasli, V. George, D. Turcu, I. Iashchishyn, L. Morozova-Roche, Ø. Halskau. FEBS Journal, 2020, 288, 1887. DOI: 10.1111/febs.15551

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals, A. Koulman, Samuel Furse, M. Baumert, G. Goldberg, L. Bluck. Rapid Communications in Mass Spectrometry, 2019, 33, 1267-1276. DOI: 10.1002/rcm.8465

Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study.  C. J. Petry, A. Koulman, L. Lu, B. J. Jenkins, Samuel Furse, P. Prentice, L. Matthews, I. A. Hughes, C. L. Acerini, K. K. Ong, D. B. Dunger. Reproductive Biology and Endocrinology, 2018, 16, 82.  DOI: 10.1186/s12958-018-0399-x.

The Role of Endogenous Lipids in the Emulsifying Properties of Cocoa. J. M. Gould, Samuel Furse and B. Wolf. Frontiers in Chemistry, 2016, 4, 11. DOI: 10.3389/fchem.2016.00011

Phytochemical Composition of Oryza sativa (Rice) Bran Oil Bodies. N. Nantiyakul, Samuel Furse, I. Fisk, G. Tucker D. A. Gray. Journal of the American Oil Chemists Society,2012, 89, 1867-1872. DOI: 10.1007/s11746-012-2078-y.

The Isolation of Oil Bodies from Oryza sativa bran and Studies of their Physical Properties. N. Nantiyakul, Samuel Furse, I. D. Fisk, G. Tucker D. A. Gray. Journal of Cereal Science,2013, 57, 141-145.  DOI: 10.1016/j.jcs.2012.11.002.

 

Reviews and Editorials

Do lipid shape the cell cycle? [Review]
Samuel Furse, Gemma C. Shearman.
 Biochimica et Biophysica Acta, 2017. DOI: http://dx.doi.org/10.1016/j.bbalip.2017.09.010.

Is phosphatidylglycerol essential for terrestrial life? [Review]
Samuel Furse.
Journal of Chemical Biology, 2016. DOI: http://dx.doi.org/10.1007/s12154-016-0159-3.

The 3D distribution of phospholipids in Gram negative bacteria [Mini-review]
Samuel Furse, David J. Scott.
Biochemistry, 2016, 55, 4742–4747.  DOI: http://dx.doi.org/10.1021/acs.biochem.6b00541.

Detection of mis-folded protein aggregates from a clinical perspective [Mini-review]
Øyvind Strømland, Martin Jakubec, Samuel Furse, Øyvind Halskau.
Journal of Clinical and Translational Research, 2016, 2, 3. http://dx.doi.org/10.18053/jctres.201604.003. 

Isolation of lipids from biological samples [Review]
Samuel Furse, Maarten R. Egmond, J. Antoinette Killian.
Molecular Membrane Biology, 2015, 32, 55-64. http://dx.doi.org/10.3109/09687688.2015.1050468.  PMID: 26212444

Phosphatidylcholine’s role beyond that of a membrane brick [Mini-review]
Samuel Furse, Anton I. P. M. de Kroon.
Molecular Membrane Biology, 2015, 32, 117-9.  DOI: http://dx.doi.org/10.3109/09687688.2015.1066894. PMID: 26306852

The physical influence of inositides – A disproportionate effect? [Mini-review]
Samuel Furse.
Journal of Chemical Biology, 2015, 8, 1-3. DOI: http://dx.doi.org/10.1007/s12154-014-0117-x. Article available on-line 2014-07-20.  PMID: 25584076.

Lipase activity in lipidomics – A hidden problem?  [Editorial]
Samuel Furse and J. Antoinette Killian.
Molecular Membrane Biology, 2013, 30, 347-9. DOI: http://dx.doi.org/10.3109/09687688.2013.835125.  PMID: 24147976.

 

Grants Awarded

The release of triglycerides from oil bodies by biochemical means, applied for Hermes Innovation Fellowship 2012 (Nottinghamshire Innovation Centre), joint applicant with Dr D. A. Gray.  Application approved with 100% funding.

Beyond carbon capture: the ecosystem service value of trees for pollinators.  Co-I with Dr Hauke Koch (PI) and Prof Phil Stevenson (Co-I).  Application to RBG Kew pilot study fund (round 10). Application approved with 100% funding (£3.8k).

Ethnicity and gestational diabetes: improving risk prediction in pregnancy in Africa and the UK.  Co-I with Dr Albert Koulman (Co-I), Prof Moffatt Nyirenda (Co-I) and Dr Claire Meek (PI).  Application to Alborada (July 2020).  Application approved with 100% funding (£20k, consumables only).

Is Gestational Diabetes Mellitus driven by a novel lipid regulatory mechanism?  Applied to the Director’s Discretionary fund (Jan 2019).  Joint application by Samuel Furse and Denise Fernandez-Twinn (group leaders: Professor Susan Ozanne & Dr Albert Koulman).  Application approved with 100% funding (£5k, consumables only).

 

Service contracts

Changes in lipid metabolism in paediatric NAFLD.  120 child and adolescent serum samples.  Collaboration with Prof Catherine Williamson and Dr Emer Fitzpatrick at KCL.  Cost: £7,830. 

Follow up of the lipid metabolism in infants from obese and obese-GDM pregnancies (UPBEAT-TEMPO trial).  320 dried blood spots.  Collaboration with Kathryn Dalrymple and Prof Lucilla Poston at KCL.  Cost: £4,640. 

Using Lipidomics to understand hepatic lipid metabolism in paediatric NAFLD.  120 child serum samples.  Collaboration with Prof Catherine Williamson and Dr Emer Fitzpatrick at KCL.  Cost: £4,730. 

 

Patents

Rapid Oil Release from Oil Bodies.  David A. Gray, Amit Khosla, Timothy J.  Foster, Elena Marasca, Samuel Furse.  2103.  UK Application Number GB 1208902.5 ref. 11-0084. International Patent Number WO 2013175203 A1

 

Other Information

If you would like any further information on these publications please contact me or the corresponding author named in the publication.

My Scopus author ID is 55048056100.

My ORCiD is 0000-0003-4267-2051, ResearcherID is F-6542-2015 and ImpactStory page is here.

My ResearchGate profile can be found here.

 

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